相互作用
Dolasetron + Ibutilide
重症度: 併用禁忌
Dolasetron and Ibutilide: contraindicated interaction.
最終更新日
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概要
Ibutilide is a class III antiarrhythmic with a high risk of torsades de pointes, and dolasetron further lengthens the QT interval. The combination can cause life-threatening arrhythmia.
この相互作用をわかりやすく説明すると
Dolasetron and Ibutilide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dolasetron belongs to Gastrointestinal Tract; Ibutilide belongs to Cardiovascular.
なぜ起こるのか
Additive prolongation of ventricular repolarization.
対処法
Do not use dolasetron around ibutilide administration. Choose an antiemetic without QT effect and maintain continuous ECG monitoring during ibutilide therapy.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DolasetronとIbutilideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Dolasetronのその他の相互作用
Ibutilideのその他の相互作用
よくある質問
Can I take Dolasetron with Ibutilide?
MediHelp rates the interaction as contraindicated. Dolasetron and Ibutilide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ibutilide is a class III antiarrhythmic with a high risk of torsades de pointes, and dolasetron further lengthens the QT interval. The combination can cause life-threatening arrhythmia.
How serious is the interaction between Dolasetron and Ibutilide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use dolasetron around ibutilide administration. Choose an antiemetic without QT effect and maintain continuous ECG monitoring during ibutilide therapy.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Pimozide. The full list is on the Dolasetron page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
