相互作用
Cholera vaccine + Cilastatin-imipenem
重症度: 中等度
Cholera vaccine and Cilastatin-imipenem: moderate interaction.
最終更新日
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概要
Live oral cholera vaccine depends on gut colonization by the attenuated strain. Imipenem is a broad-spectrum antibiotic that may eliminate the strain and reduce the vaccine response. This could leave the patient inadequately protected.
この相互作用をわかりやすく説明すると
Cholera vaccine and Cilastatin-imipenem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
なぜ起こるのか
Antibacterial activity against the live attenuated vaccine strain reduces its replication and immunogenicity.
対処法
Avoid vaccination within 14 days after systemic antibiotics, per labeling. Postpone elective vaccination or revaccinate after the course ends.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Cholera vaccineとCilastatin-imipenemの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Cilastatin-imipenemのその他の相互作用
よくある質問
Can I take Cholera vaccine with Cilastatin-imipenem?
MediHelp rates the interaction as moderate. Cholera vaccine and Cilastatin-imipenem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Live oral cholera vaccine depends on gut colonization by the attenuated strain. Imipenem is a broad-spectrum antibiotic that may eliminate the strain and reduce the vaccine response. This could leave the patient inadequately protected.
How serious is the interaction between Cholera vaccine and Cilastatin-imipenem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid vaccination within 14 days after systemic antibiotics, per labeling. Postpone elective vaccination or revaccinate after the course ends.
What other medicines interact with Cilastatin-imipenem?
MediHelp also lists interactions of Cilastatin-imipenem with, for example, Divalproex, Ganciclovir, Valproic acid. The full list is on the Cilastatin-imipenem page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
