医薬品リファレンス
Cilastatin-imipenem
Cilastatin-imipenem is a medicine in the class anti bacterial. It is used for pseudomonal infections.
- 薬効分類: Anti Bacterial
- 効能・効果: pseudomonal infections
最終更新日
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要点
- 薬効分類
- Anti Bacterial
- 一般的な剤形
- 注射剤
- 一般的な規格
- 500 mg, 500 mg/100 ml
- 既知の相互作用
- 13 (重大: 3 · 中等度: 10)
- 商品名
- 8
- 国・市場
- 3
何に使われるか
作用のしくみ
Imipenem inhibits bacterial cell-wall synthesis by binding to penicillin-binding proteins; cilastatin prevents renal metabolism of imipenem.
成人の通常用量（添付文書の要約）
Lower Respiratory Tract, Skin/Skin Structure, & Gynecologic Infections (Mild to moderate): 500-750 mg IV q12hr
妊娠と授乳
- 妊娠
- Safe Human data are limited and do not show a risk of birth defects; in monkeys, doses similar to the human dose increased embryo loss. Beta-lactam antibiotics are generally acceptable in pregnancy; use when needed for serious infection.
- 授乳
- Safe Passes into milk in small amounts and is poorly absorbed orally. LactMed: acceptable; watch the infant for diarrhoea, rash or thrush.
報告されている副作用
- Phlebitis
- Eosinophilia
- Miscellaneous dermatologic effects
- Potentially false-positive Coombs test
- Miscellaneous hematologic effects
注意が必要な方
- Use with caution in renal impairment; adjust dosage in moderate to severe renal dysfunction
- Carbapenem use may decrease serum levels of divalproex sodium or valproic acid
- Combination with aminoglycosides may thwart resistant P aeruginosa
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (13)
- Cilastatin-imipenem + Divalproex Major
- Cilastatin-imipenem + Ganciclovir Major
- Cilastatin-imipenem + Valproic acid Major
- Bcg intravesical live + Cilastatin-imipenem Moderate
- Bcg vaccine live + Cilastatin-imipenem Moderate
- Cholera vaccine + Cilastatin-imipenem Moderate
- Cilastatin-imipenem + Cyclosporine Moderate
- Cilastatin-imipenem + Microbiota Moderate
- Cilastatin-imipenem + Probenecid Moderate
- Cilastatin-imipenem + Sodium picosulfate Moderate
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Cilastatin-imipenemの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
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同じ分類のほかの薬剤
よくある質問
What is Cilastatin-imipenem used for?
Cilastatin-imipenem is a medicine in the class anti bacterial. It is used for Pseudomonal infections, Respiratory tract infections, Sepsis, Skin infections, Urinary tract infections.
What side effects have been reported with Cilastatin-imipenem?
Phlebitis, Eosinophilia, Miscellaneous dermatologic effects, Potentially false-positive Coombs test, Miscellaneous hematologic effects.
Can Cilastatin-imipenem be taken in pregnancy or while breastfeeding?
Pregnancy: Safe. Human data are limited and do not show a risk of birth defects; in monkeys, doses similar to the human dose increased embryo loss. Beta-lactam antibiotics are generally acceptable in pregnancy; use when needed for serious infection. Breastfeeding: Safe. Passes into milk in small amounts and is poorly absorbed orally. LactMed: acceptable; watch the infant for diarrhoea, rash or thrush.
What does Cilastatin-imipenem interact with?
MediHelp lists 13 known interactions for Cilastatin-imipenem. Major: 3 · Moderate: 10. The most serious include Divalproex, Ganciclovir, Valproic acid.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
