相互作用
Cimetidine + Theophylline
重症度: 重大
Cimetidine and Theophylline: major interaction.
最終更新日 出典: US FDA label
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概要
Cimetidine reduces theophylline clearance and can substantially raise serum levels, risking nausea, tachycardia, arrhythmia and seizures. Theophylline has a narrow therapeutic index so this is clinically important.
この相互作用をわかりやすく説明すると
Cimetidine and Theophylline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cimetidine belongs to Gastrointestinal Tract; Theophylline belongs to Respiratory.
なぜ起こるのか
Cimetidine inhibits CYP1A2 (and CYP3A4), decreasing theophylline metabolism.
対処法
Prefer an alternative acid suppressant such as famotidine or a proton pump inhibitor. If combined, reduce the theophylline dose and monitor serum concentrations.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CimetidineとTheophyllineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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参考文献
- Theophylline (Anhydrous) - FDA drug label (DailyMed) — openFDA / DailyMed
Theophyllineのその他の相互作用
Cimetidineのその他の相互作用
よくある質問
Can I take Cimetidine with Theophylline?
MediHelp rates the interaction as major. Cimetidine and Theophylline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cimetidine reduces theophylline clearance and can substantially raise serum levels, risking nausea, tachycardia, arrhythmia and seizures. Theophylline has a narrow therapeutic index so this is clinically important.
How serious is the interaction between Cimetidine and Theophylline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative acid suppressant such as famotidine or a proton pump inhibitor. If combined, reduce the theophylline dose and monitor serum concentrations.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
