相互作用
Ciprofloxacin + Theophylline
重症度: 重大
Ciprofloxacin and Theophylline: major interaction.
最終更新日 出典: US FDA label
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概要
Ciprofloxacin reduces theophylline clearance and can raise serum theophylline concentrations substantially in some patients. This can lead to nausea, tachycardia, arrhythmias and seizures. Elderly patients, those with high baseline levels, liver disease or heart failure, and smokers who stop are at greater risk.
この相互作用をわかりやすく説明すると
Ciprofloxacin and Theophylline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ciprofloxacin belongs to Anti Bacterial; Theophylline belongs to Respiratory.
なぜ起こるのか
Ciprofloxacin inhibits CYP1A2, the main enzyme metabolising theophylline, decreasing its clearance.
対処法
Prefer an antibiotic that does not inhibit CYP1A2. If ciprofloxacin is needed, measure theophylline levels before and during therapy and reduce the theophylline dose empirically.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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アカウントを作成してPro+トライアルを始めると、CiprofloxacinとTheophyllineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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参考文献
Theophyllineのその他の相互作用
Ciprofloxacinのその他の相互作用
よくある質問
Can I take Ciprofloxacin with Theophylline?
MediHelp rates the interaction as major. Ciprofloxacin and Theophylline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ciprofloxacin reduces theophylline clearance and can raise serum theophylline concentrations substantially in some patients. This can lead to nausea, tachycardia, arrhythmias and seizures. Elderly patients, those with high baseline levels, liver disease or heart failure, and smokers who stop are at greater risk.
How serious is the interaction between Ciprofloxacin and Theophylline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antibiotic that does not inhibit CYP1A2. If ciprofloxacin is needed, measure theophylline levels before and during therapy and reduce the theophylline dose empirically.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
