相互作用
Ciprofloxacin + Cobimetinib
重症度: 重大
Ciprofloxacin and Cobimetinib: major interaction.
最終更新日
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概要
Cobimetinib is a CYP3A substrate, and ciprofloxacin is a moderate CYP3A inhibitor according to cobimetinib labeling. Co-use may raise cobimetinib exposure and increase its adverse effects, such as hemorrhage, rhabdomyolysis, liver toxicity and retinopathy.
この相互作用をわかりやすく説明すると
Ciprofloxacin and Cobimetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ciprofloxacin belongs to Anti Bacterial; Cobimetinib belongs to Oncology.
なぜ起こるのか
Ciprofloxacin inhibits CYP3A4, reducing cobimetinib metabolism and raising its exposure.
対処法
Prefer an alternative antibiotic. If a moderate CYP3A inhibitor is needed for 14 days or less, cobimetinib labeling recommends reducing the dose to 20 mg, and the usual dose is resumed after the inhibitor is stopped.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CiprofloxacinとCobimetinibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Ciprofloxacinのその他の相互作用
Cobimetinibのその他の相互作用
よくある質問
Can I take Ciprofloxacin with Cobimetinib?
MediHelp rates the interaction as major. Ciprofloxacin and Cobimetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cobimetinib is a CYP3A substrate, and ciprofloxacin is a moderate CYP3A inhibitor according to cobimetinib labeling. Co-use may raise cobimetinib exposure and increase its adverse effects, such as hemorrhage, rhabdomyolysis, liver toxicity and retinopathy.
How serious is the interaction between Ciprofloxacin and Cobimetinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antibiotic. If a moderate CYP3A inhibitor is needed for 14 days or less, cobimetinib labeling recommends reducing the dose to 20 mg, and the usual dose is resumed after the inhibitor is stopped.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
