相互作用
Cisplatin + Vancomycin
重症度: 重大
Cisplatin and Vancomycin: major interaction.
最終更新日
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概要
Cisplatin is markedly nephrotoxic and ototoxic, and vancomycin adds further renal risk. The combination raises the likelihood of acute kidney injury, and reduced clearance may in turn increase vancomycin levels and cisplatin-related hearing loss.
この相互作用をわかりやすく説明すると
Cisplatin and Vancomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cisplatin belongs to Oncology; Vancomycin belongs to Anti Bacterial.
なぜ起こるのか
Additive proximal tubular toxicity, with reduced renal clearance increasing exposure to both drugs.
対処法
Use an alternative to vancomycin when possible. If necessary, monitor serum creatinine, magnesium and vancomycin levels closely, ensure hydration, and consider audiometry.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CisplatinとVancomycinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Vancomycinのその他の相互作用
Cisplatinのその他の相互作用
よくある質問
Can I take Cisplatin with Vancomycin?
MediHelp rates the interaction as major. Cisplatin and Vancomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cisplatin is markedly nephrotoxic and ototoxic, and vancomycin adds further renal risk. The combination raises the likelihood of acute kidney injury, and reduced clearance may in turn increase vancomycin levels and cisplatin-related hearing loss.
How serious is the interaction between Cisplatin and Vancomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative to vancomycin when possible. If necessary, monitor serum creatinine, magnesium and vancomycin levels closely, ensure hydration, and consider audiometry.
What other medicines interact with Vancomycin?
MediHelp also lists interactions of Vancomycin with, for example, Amikacin, Bacitracin, Capreomycin. The full list is on the Vancomycin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
