相互作用
Colistin + Vancomycin
重症度: 重大
Colistin and Vancomycin: major interaction.
最終更新日
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概要
Both vancomycin and colistin are nephrotoxic, and combination therapy has been associated with a higher incidence of acute kidney injury than either drug alone. Colistin also carries neurotoxicity risk.
この相互作用をわかりやすく説明すると
Colistin and Vancomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Colistin belongs to Anti Bacterial; Vancomycin belongs to Anti Bacterial.
なぜ起こるのか
Additive tubular nephrotoxicity from both drugs.
対処法
Monitor serum creatinine and urine output daily and use vancomycin level-guided dosing. Consider alternatives to vancomycin if gram-positive coverage is not essential.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ColistinとVancomycinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Vancomycinのその他の相互作用
Colistinのその他の相互作用
よくある質問
Can I take Colistin with Vancomycin?
MediHelp rates the interaction as major. Colistin and Vancomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both vancomycin and colistin are nephrotoxic, and combination therapy has been associated with a higher incidence of acute kidney injury than either drug alone. Colistin also carries neurotoxicity risk.
How serious is the interaction between Colistin and Vancomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and urine output daily and use vancomycin level-guided dosing. Consider alternatives to vancomycin if gram-positive coverage is not essential.
What other medicines interact with Vancomycin?
MediHelp also lists interactions of Vancomycin with, for example, Amikacin, Bacitracin, Capreomycin. The full list is on the Vancomycin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
