相互作用
Clarithromycin + Cobimetinib
重症度: 重大
Clarithromycin and Cobimetinib: major interaction.
最終更新日
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概要
Clarithromycin, a strong CYP3A4 inhibitor, markedly increases cobimetinib exposure and may raise the risk of adverse effects such as hemorrhage, serous retinopathy, rhabdomyolysis, and cardiomyopathy.
この相互作用をわかりやすく説明すると
Clarithromycin and Cobimetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clarithromycin belongs to Anti Bacterial; Cobimetinib belongs to Oncology.
なぜ起こるのか
Clarithromycin inhibits CYP3A4-mediated metabolism of cobimetinib, greatly increasing its exposure.
対処法
Avoid the combination and use a non-CYP3A4-inhibiting antibiotic such as azithromycin. If a strong inhibitor is short-term unavoidable, reduce cobimetinib dose per labeling and monitor closely.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ClarithromycinとCobimetinibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Clarithromycinのその他の相互作用
Cobimetinibのその他の相互作用
よくある質問
Can I take Clarithromycin with Cobimetinib?
MediHelp rates the interaction as major. Clarithromycin and Cobimetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin, a strong CYP3A4 inhibitor, markedly increases cobimetinib exposure and may raise the risk of adverse effects such as hemorrhage, serous retinopathy, rhabdomyolysis, and cardiomyopathy.
How serious is the interaction between Clarithromycin and Cobimetinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-CYP3A4-inhibiting antibiotic such as azithromycin. If a strong inhibitor is short-term unavoidable, reduce cobimetinib dose per labeling and monitor closely.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
