相互作用
Clarithromycin + Paricalcitol
重症度: 中等度
Clarithromycin and Paricalcitol: moderate interaction.
最終更新日
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概要
Paricalcitol is partly metabolized by CYP3A4, so clarithromycin may raise its exposure. This could lead to hypercalcemia or hyperphosphatemia, particularly with prolonged use.
この相互作用をわかりやすく説明すると
Clarithromycin and Paricalcitol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clarithromycin belongs to Anti Bacterial; Paricalcitol belongs to Musculoskeletal.
なぜ起こるのか
Clarithromycin inhibits CYP3A4 metabolism of paricalcitol.
対処法
Monitor serum calcium, phosphate and PTH during and after the antibiotic course, and lower the paricalcitol dose if hypercalcemia develops.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ClarithromycinとParicalcitolの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Clarithromycinのその他の相互作用
Paricalcitolのその他の相互作用
よくある質問
Can I take Clarithromycin with Paricalcitol?
MediHelp rates the interaction as moderate. Clarithromycin and Paricalcitol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paricalcitol is partly metabolized by CYP3A4, so clarithromycin may raise its exposure. This could lead to hypercalcemia or hyperphosphatemia, particularly with prolonged use.
How serious is the interaction between Clarithromycin and Paricalcitol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium, phosphate and PTH during and after the antibiotic course, and lower the paricalcitol dose if hypercalcemia develops.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
