相互作用
Paricalcitol + Posaconazole
重症度: 中等度
Paricalcitol and Posaconazole: moderate interaction.
最終更新日
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概要
Posaconazole may increase paricalcitol exposure, which could lead to hypercalcemia or excessive suppression of parathyroid hormone. The effect of strong CYP3A4 inhibition is typically modest.
この相互作用をわかりやすく説明すると
Paricalcitol and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paricalcitol belongs to Musculoskeletal; Posaconazole belongs to Anti Fungals.
なぜ起こるのか
Posaconazole inhibits CYP3A4, which contributes to paricalcitol metabolism.
対処法
Monitor serum calcium, phosphate and PTH, and reduce the paricalcitol dose if hypercalcemia occurs.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ParicalcitolとPosaconazoleの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Posaconazoleのその他の相互作用
Paricalcitolのその他の相互作用
よくある質問
Can I take Paricalcitol with Posaconazole?
MediHelp rates the interaction as moderate. Paricalcitol and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole may increase paricalcitol exposure, which could lead to hypercalcemia or excessive suppression of parathyroid hormone. The effect of strong CYP3A4 inhibition is typically modest.
How serious is the interaction between Paricalcitol and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium, phosphate and PTH, and reduce the paricalcitol dose if hypercalcemia occurs.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
