相互作用
Darunavir + Regorafenib
重症度: 重大
Darunavir and Regorafenib: major interaction.
最終更新日
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概要
Darunavir, especially when boosted with ritonavir or cobicistat, strongly inhibits CYP3A4 and may increase regorafenib exposure, with unpredictable changes in active metabolites.
この相互作用をわかりやすく説明すると
Darunavir and Regorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Darunavir belongs to Anti Virals; Regorafenib belongs to Oncology.
なぜ起こるのか
CYP3A4 inhibition by boosted darunavir reduces regorafenib clearance.
対処法
Avoid the combination if possible. If coadministration is necessary, monitor liver function and for adverse reactions.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DarunavirとRegorafenibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を7日間無料でお試し。カード登録不要。
Regorafenibのその他の相互作用
Darunavirのその他の相互作用
よくある質問
Can I take Darunavir with Regorafenib?
MediHelp rates the interaction as major. Darunavir and Regorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Darunavir, especially when boosted with ritonavir or cobicistat, strongly inhibits CYP3A4 and may increase regorafenib exposure, with unpredictable changes in active metabolites.
How serious is the interaction between Darunavir and Regorafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If coadministration is necessary, monitor liver function and for adverse reactions.
What other medicines interact with Regorafenib?
MediHelp also lists interactions of Regorafenib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Regorafenib page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
