相互作用
Clemastine + Fentanyl intranasal
重症度: 重大
Clemastine and Fentanyl intranasal: major interaction.
最終更新日
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概要
Fentanyl is a potent opioid and clemastine is a sedating antimuscarinic antihistamine. Together they increase sedation and may raise the risk of respiratory depression, and additive anticholinergic effects can worsen urinary retention and constipation, potentially leading to ileus.
この相互作用をわかりやすく説明すると
Clemastine and Fentanyl intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Additive central nervous system and respiratory depression plus additive antimuscarinic effects on gut and bladder.
対処法
Use the lowest effective doses and monitor sedation and respiratory rate. Monitor for constipation and urinary retention and consider a non-sedating antihistamine.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ClemastineとFentanyl intranasalの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Clemastineのその他の相互作用
よくある質問
Can I take Clemastine with Fentanyl intranasal?
MediHelp rates the interaction as major. Clemastine and Fentanyl intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fentanyl is a potent opioid and clemastine is a sedating antimuscarinic antihistamine. Together they increase sedation and may raise the risk of respiratory depression, and additive anticholinergic effects can worsen urinary retention and constipation, potentially leading to ileus.
How serious is the interaction between Clemastine and Fentanyl intranasal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and respiratory rate. Monitor for constipation and urinary retention and consider a non-sedating antihistamine.
What other medicines interact with Clemastine?
MediHelp also lists interactions of Clemastine with, for example, Alfentanil, Benzhydrocodone / acetaminophen, Buprenorphine buccal. The full list is on the Clemastine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
