相互作用
Clomipramine + Dofetilide
重症度: 併用禁忌
Clomipramine and Dofetilide: contraindicated interaction.
最終更新日
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概要
Both drugs prolong the QT interval, and dofetilide carries a substantial risk of torsades de pointes. Adding clomipramine can raise this risk further.
この相互作用をわかりやすく説明すると
Clomipramine and Dofetilide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clomipramine belongs to Central Nervous System; Dofetilide belongs to Cardiovascular.
なぜ起こるのか
Additive QT prolongation through potassium channel (hERG) blockade.
対処法
Avoid the combination and choose an antidepressant with less QT effect. Correct potassium and magnesium disturbances in any patient on dofetilide.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ClomipramineとDofetilideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Clomipramineのその他の相互作用
Dofetilideのその他の相互作用
よくある質問
Can I take Clomipramine with Dofetilide?
MediHelp rates the interaction as contraindicated. Clomipramine and Dofetilide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, and dofetilide carries a substantial risk of torsades de pointes. Adding clomipramine can raise this risk further.
How serious is the interaction between Clomipramine and Dofetilide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an antidepressant with less QT effect. Correct potassium and magnesium disturbances in any patient on dofetilide.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Droperidol, Isocarboxazid. The full list is on the Clomipramine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
