相互作用
Clomipramine + Isocarboxazid
重症度: 併用禁忌
Clomipramine and Isocarboxazid: contraindicated interaction.
最終更新日
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概要
Clomipramine is a potent serotonin and noradrenaline reuptake inhibitor, and isocarboxazid (an irreversible non-selective MAO inhibitor) blocks monoamine breakdown. Serotonin syndrome and hypertensive crisis are the main dangers.
この相互作用をわかりやすく説明すると
Clomipramine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clomipramine belongs to Central Nervous System; Isocarboxazid belongs to Central Nervous System.
なぜ起こるのか
Monoamine reuptake inhibition plus MAO inhibition
対処法
Do not use together. Wait at least 14 days after stopping isocarboxazid before starting the other drug; leave about 2 weeks after stopping clomipramine before starting an irreversible MAOI.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ClomipramineとIsocarboxazidの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Clomipramineのその他の相互作用
Isocarboxazidのその他の相互作用
よくある質問
Can I take Clomipramine with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Clomipramine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Clomipramine is a potent serotonin and noradrenaline reuptake inhibitor, and isocarboxazid (an irreversible non-selective MAO inhibitor) blocks monoamine breakdown. Serotonin syndrome and hypertensive crisis are the main dangers.
How serious is the interaction between Clomipramine and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Wait at least 14 days after stopping isocarboxazid before starting the other drug; leave about 2 weeks after stopping clomipramine before starting an irreversible MAOI.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
