相互作用
Cobicistat + Midazolam
重症度: 併用禁忌
Cobicistat and Midazolam: contraindicated interaction.
最終更新日
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概要
Cobicistat strongly inhibits CYP3A and can greatly increase midazolam exposure, particularly after oral dosing. Prolonged sedation and respiratory depression can occur and are potentially life-threatening.
この相互作用をわかりやすく説明すると
Cobicistat and Midazolam are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cobicistat belongs to Miscellaneous; Midazolam belongs to Central Nervous System.
なぜ起こるのか
Cobicistat inhibits intestinal and hepatic CYP3A4, blocking midazolam first-pass and systemic metabolism.
対処法
Avoid oral midazolam. If single-dose parenteral midazolam is needed, use a reduced dose in a monitored setting with respiratory support available.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CobicistatとMidazolamの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Midazolamのその他の相互作用
Cobicistatのその他の相互作用
よくある質問
Can I take Cobicistat with Midazolam?
MediHelp rates the interaction as contraindicated. Cobicistat and Midazolam are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cobicistat strongly inhibits CYP3A and can greatly increase midazolam exposure, particularly after oral dosing. Prolonged sedation and respiratory depression can occur and are potentially life-threatening.
How serious is the interaction between Cobicistat and Midazolam?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid oral midazolam. If single-dose parenteral midazolam is needed, use a reduced dose in a monitored setting with respiratory support available.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df. The full list is on the Midazolam page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
