相互作用
Darunavir + Midazolam
重症度: 併用禁忌
Darunavir and Midazolam: contraindicated interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Darunavir, usually boosted with ritonavir or cobicistat, inhibits CYP3A and raises midazolam exposure considerably. Oral midazolam may cause prolonged sedation and respiratory depression.
この相互作用をわかりやすく説明すると
Darunavir and Midazolam are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Darunavir belongs to Anti Virals; Midazolam belongs to Central Nervous System.
なぜ起こるのか
Boosted darunavir inhibits CYP3A4 metabolism of midazolam.
対処法
Avoid oral midazolam. If parenteral midazolam is needed, lower the dose and monitor respiratory function.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DarunavirとMidazolamの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Midazolamのその他の相互作用
Darunavirのその他の相互作用
よくある質問
Can I take Darunavir with Midazolam?
MediHelp rates the interaction as contraindicated. Darunavir and Midazolam are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Darunavir, usually boosted with ritonavir or cobicistat, inhibits CYP3A and raises midazolam exposure considerably. Oral midazolam may cause prolonged sedation and respiratory depression.
How serious is the interaction between Darunavir and Midazolam?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid oral midazolam. If parenteral midazolam is needed, lower the dose and monitor respiratory function.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Elvitegravir / cobicistat / emtricitabine / tenofovir df. The full list is on the Midazolam page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
