相互作用
Itraconazole + Midazolam
重症度: 併用禁忌
Itraconazole and Midazolam: contraindicated interaction.
最終更新日
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概要
Itraconazole is a strong CYP3A4 inhibitor and raises midazolam exposure many-fold, especially with the oral route. Prolonged sedation and respiratory depression can occur.
この相互作用をわかりやすく説明すると
Itraconazole and Midazolam are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Itraconazole belongs to Anti Fungals; Midazolam belongs to Central Nervous System.
なぜ起こるのか
Strong CYP3A4 inhibition markedly raises midazolam exposure
対処法
Oral midazolam is contraindicated; if IV midazolam is unavoidable, use a reduced dose with continuous monitoring.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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アカウントを作成してPro+トライアルを始めると、ItraconazoleとMidazolamの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Itraconazoleのその他の相互作用
Midazolamのその他の相互作用
よくある質問
Can I take Itraconazole with Midazolam?
MediHelp rates the interaction as contraindicated. Itraconazole and Midazolam are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Itraconazole is a strong CYP3A4 inhibitor and raises midazolam exposure many-fold, especially with the oral route. Prolonged sedation and respiratory depression can occur.
How serious is the interaction between Itraconazole and Midazolam?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Oral midazolam is contraindicated; if IV midazolam is unavoidable, use a reduced dose with continuous monitoring.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
