相互作用
Indinavir + Midazolam
重症度: 併用禁忌
Indinavir and Midazolam: contraindicated interaction.
最終更新日
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概要
Indinavir inhibits CYP3A4 and can increase midazolam exposure, leading to excessive and prolonged sedation and respiratory depression.
この相互作用をわかりやすく説明すると
Indinavir and Midazolam are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Indinavir inhibits CYP3A4 metabolism of midazolam.
対処法
Avoid oral midazolam. If parenteral dosing is needed, reduce the dose and monitor sedation and respiration.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、IndinavirとMidazolamの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Midazolamのその他の相互作用
よくある質問
Can I take Indinavir with Midazolam?
MediHelp rates the interaction as contraindicated. Indinavir and Midazolam are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Indinavir inhibits CYP3A4 and can increase midazolam exposure, leading to excessive and prolonged sedation and respiratory depression.
How serious is the interaction between Indinavir and Midazolam?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid oral midazolam. If parenteral dosing is needed, reduce the dose and monitor sedation and respiration.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
