相互作用
Cocaine + Phenylephrine
重症度: 重大
Cocaine and Phenylephrine: major interaction.
最終更新日
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概要
Cocaine combined with phenylephrine can cause additive vasoconstriction and pressor effects, increasing the risk of severe hypertension, myocardial ischemia and arrhythmia.
この相互作用をわかりやすく説明すると
Cocaine and Phenylephrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cocaine belongs to Central Nervous System; Phenylephrine belongs to Respiratory.
なぜ起こるのか
Additive sympathomimetic effects: cocaine reuptake blockade plus alpha-1 agonism.
対処法
Avoid additional vasoconstrictors where possible. If unavoidable, use the lowest dose with prolonged ECG and blood pressure monitoring.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CocaineとPhenylephrineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Cocaineのその他の相互作用
Phenylephrineのその他の相互作用
よくある質問
Can I take Cocaine with Phenylephrine?
MediHelp rates the interaction as major. Cocaine and Phenylephrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cocaine combined with phenylephrine can cause additive vasoconstriction and pressor effects, increasing the risk of severe hypertension, myocardial ischemia and arrhythmia.
How serious is the interaction between Cocaine and Phenylephrine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid additional vasoconstrictors where possible. If unavoidable, use the lowest dose with prolonged ECG and blood pressure monitoring.
What other medicines interact with Cocaine?
MediHelp also lists interactions of Cocaine with, for example, Isocarboxazid, Phenelzine, Procarbazine. The full list is on the Cocaine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
