相互作用
Isocarboxazid + Phenylephrine
重症度: 併用禁忌
Isocarboxazid and Phenylephrine: contraindicated interaction.
最終更新日
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概要
Isocarboxazid irreversibly inhibits monoamine oxidase, and phenylephrine is a direct alpha-1 agonist; with MAO inhibition pressor response is potentiated because MAO inhibition reduces catecholamine breakdown and sensitises tissues. Heart-rate and blood pressure rises, arrhythmia or a hypertensive crisis can result.
この相互作用をわかりやすく説明すると
Isocarboxazid and Phenylephrine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isocarboxazid belongs to Central Nervous System; Phenylephrine belongs to Respiratory.
なぜ起こるのか
MAO inhibition potentiating sympathomimetic/pressor activity
対処法
Do not co-administer; wait at least 14 days after stopping the MAO inhibitor before using it.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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アカウントを作成してPro+トライアルを始めると、IsocarboxazidとPhenylephrineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Phenylephrineのその他の相互作用
Isocarboxazidのその他の相互作用
よくある質問
Can I take Isocarboxazid with Phenylephrine?
MediHelp rates the interaction as contraindicated. Isocarboxazid and Phenylephrine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Isocarboxazid irreversibly inhibits monoamine oxidase, and phenylephrine is a direct alpha-1 agonist; with MAO inhibition pressor response is potentiated because MAO inhibition reduces catecholamine breakdown and sensitises tissues. Heart-rate and blood pressure rises, arrhythmia or a hypertensive crisis can result.
How serious is the interaction between Isocarboxazid and Phenylephrine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; wait at least 14 days after stopping the MAO inhibitor before using it.
What other medicines interact with Phenylephrine?
MediHelp also lists interactions of Phenylephrine with, for example, Phenelzine, Tranylcypromine, Bromocriptine. The full list is on the Phenylephrine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
