相互作用
Colchicine + Levoketoconazole
重症度: 併用禁忌
Colchicine and Levoketoconazole: contraindicated interaction.
最終更新日
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概要
Levoketoconazole is a strong CYP3A4 and P-gp inhibitor and can markedly raise colchicine levels. This risks severe colchicine toxicity, with the greatest danger in renal or hepatic impairment.
この相互作用をわかりやすく説明すると
Colchicine and Levoketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Colchicine belongs to Genitourinary; Levoketoconazole belongs to Endocrine.
なぜ起こるのか
Levoketoconazole inhibits CYP3A4 metabolism and P-gp efflux of colchicine.
対処法
Avoid the combination, especially in renal or hepatic impairment. Use a different agent for the colchicine indication where possible.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、ColchicineとLevoketoconazoleの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Colchicineのその他の相互作用
Levoketoconazoleのその他の相互作用
よくある質問
Can I take Colchicine with Levoketoconazole?
MediHelp rates the interaction as contraindicated. Colchicine and Levoketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levoketoconazole is a strong CYP3A4 and P-gp inhibitor and can markedly raise colchicine levels. This risks severe colchicine toxicity, with the greatest danger in renal or hepatic impairment.
How serious is the interaction between Colchicine and Levoketoconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination, especially in renal or hepatic impairment. Use a different agent for the colchicine indication where possible.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
