Drug interactions
Colchicine + Levoketoconazole
Severity: Contraindicated
Colchicine and Levoketoconazole: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 and P-gp inhibitor and can markedly raise colchicine levels. This risks severe colchicine toxicity, with the greatest danger in renal or hepatic impairment.
What this interaction means in plain words
Colchicine and Levoketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Colchicine belongs to Genitourinary; Levoketoconazole belongs to Endocrine.
Why it happens
Levoketoconazole inhibits CYP3A4 metabolism and P-gp efflux of colchicine.
What to do
Avoid the combination, especially in renal or hepatic impairment. Use a different agent for the colchicine indication where possible.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
- Colchicine + Nirmatrelvir / ritonavir Contraindicated
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Colchicine with Levoketoconazole?
MediHelp rates the interaction as contraindicated. Colchicine and Levoketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levoketoconazole is a strong CYP3A4 and P-gp inhibitor and can markedly raise colchicine levels. This risks severe colchicine toxicity, with the greatest danger in renal or hepatic impairment.
How serious is the interaction between Colchicine and Levoketoconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination, especially in renal or hepatic impairment. Use a different agent for the colchicine indication where possible.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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