相互作用
Colchicine + Ensitrelvir
重症度: 併用禁忌
Colchicine and Ensitrelvir: contraindicated interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Ensitrelvir raises colchicine exposure through CYP3A inhibition and likely P-gp effects. This can produce colchicine toxicity including myelosuppression, neuromuscular toxicity and multiorgan failure, particularly in renal or hepatic impairment.
この相互作用をわかりやすく説明すると
Colchicine and Ensitrelvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Colchicine belongs to Genitourinary; Ensitrelvir belongs to Anti Virals.
なぜ起こるのか
Inhibition of CYP3A (and possibly P-glycoprotein) decreases colchicine clearance.
対処法
Avoid the combination; use an alternative COVID-19 treatment or hold colchicine only under specialist guidance.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ColchicineとEnsitrelvirの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Ensitrelvirのその他の相互作用
Colchicineのその他の相互作用
よくある質問
Can I take Colchicine with Ensitrelvir?
MediHelp rates the interaction as contraindicated. Colchicine and Ensitrelvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ensitrelvir raises colchicine exposure through CYP3A inhibition and likely P-gp effects. This can produce colchicine toxicity including myelosuppression, neuromuscular toxicity and multiorgan failure, particularly in renal or hepatic impairment.
How serious is the interaction between Colchicine and Ensitrelvir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use an alternative COVID-19 treatment or hold colchicine only under specialist guidance.
What other medicines interact with Ensitrelvir?
MediHelp also lists interactions of Ensitrelvir with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Ensitrelvir page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
