相互作用
Colchicine + Nirmatrelvir / ritonavir
重症度: 併用禁忌
Colchicine and Nirmatrelvir / ritonavir: contraindicated interaction.
最終更新日
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概要
Ritonavir strongly inhibits CYP3A4 and P-glycoprotein and can greatly raise colchicine levels. This may cause fatal colchicine toxicity including bone marrow suppression, multiorgan failure and neuromuscular toxicity, especially in renal or hepatic impairment.
この相互作用をわかりやすく説明すると
Colchicine and Nirmatrelvir / ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Inhibition of CYP3A4 and P-glycoprotein by ritonavir reduces colchicine clearance.
対処法
Avoid the combination; hold colchicine during the antiviral course or choose an alternative. Do not combine in patients with renal or hepatic impairment.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ColchicineとNirmatrelvir / ritonavirの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Colchicineのその他の相互作用
よくある質問
Can I take Colchicine with Nirmatrelvir / ritonavir?
MediHelp rates the interaction as contraindicated. Colchicine and Nirmatrelvir / ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ritonavir strongly inhibits CYP3A4 and P-glycoprotein and can greatly raise colchicine levels. This may cause fatal colchicine toxicity including bone marrow suppression, multiorgan failure and neuromuscular toxicity, especially in renal or hepatic impairment.
How serious is the interaction between Colchicine and Nirmatrelvir / ritonavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; hold colchicine during the antiviral course or choose an alternative. Do not combine in patients with renal or hepatic impairment.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
