相互作用
Cyclophosphamide + Idarubicin
重症度: 重大
Cyclophosphamide and Idarubicin: major interaction.
最終更新日
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概要
Both drugs are cardiotoxic, and giving them together may increase the risk of cardiomyopathy and heart failure beyond that of idarubicin alone. Additive myelosuppression is also expected.
この相互作用をわかりやすく説明すると
Cyclophosphamide and Idarubicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclophosphamide belongs to Oncology; Idarubicin belongs to Oncology.
なぜ起こるのか
Additive cardiotoxicity, possibly via increased formation of toxic anthracycline metabolites in myocardium, plus additive myelosuppression.
対処法
Assess left ventricular function before and during treatment, and keep cumulative anthracycline dose within recommended limits. Monitor blood counts and consider cardioprotective measures in high-risk patients.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CyclophosphamideとIdarubicinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Cyclophosphamideのその他の相互作用
Idarubicinのその他の相互作用
よくある質問
Can I take Cyclophosphamide with Idarubicin?
MediHelp rates the interaction as major. Cyclophosphamide and Idarubicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are cardiotoxic, and giving them together may increase the risk of cardiomyopathy and heart failure beyond that of idarubicin alone. Additive myelosuppression is also expected.
How serious is the interaction between Cyclophosphamide and Idarubicin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess left ventricular function before and during treatment, and keep cumulative anthracycline dose within recommended limits. Monitor blood counts and consider cardioprotective measures in high-risk patients.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
