相互作用
Daridorexant + Mifepristone
重症度: 重大
Daridorexant and Mifepristone: major interaction.
最終更新日
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概要
Mifepristone inhibits CYP3A4 and is expected to raise daridorexant exposure. This can cause excessive sedation, next-day impairment and somnolence.
この相互作用をわかりやすく説明すると
Daridorexant and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Daridorexant belongs to Central Nervous System; Mifepristone belongs to Endocrine.
なぜ起こるのか
CYP3A4 inhibition reduces daridorexant metabolism.
対処法
Avoid the combination, as strong CYP3A4 inhibitors are not recommended with daridorexant. Choose a hypnotic not dependent on CYP3A4.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、DaridorexantとMifepristoneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Mifepristoneのその他の相互作用
Daridorexantのその他の相互作用
よくある質問
Can I take Daridorexant with Mifepristone?
MediHelp rates the interaction as major. Daridorexant and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mifepristone inhibits CYP3A4 and is expected to raise daridorexant exposure. This can cause excessive sedation, next-day impairment and somnolence.
How serious is the interaction between Daridorexant and Mifepristone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination, as strong CYP3A4 inhibitors are not recommended with daridorexant. Choose a hypnotic not dependent on CYP3A4.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
