相互作用
Nizatidine + Rilpivirine
重症度: 重大
Nizatidine and Rilpivirine: major interaction.
最終更新日
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概要
Rilpivirine needs an acidic stomach for adequate absorption, and nizatidine raises gastric pH. Lower rilpivirine levels may lead to virologic failure and development of resistance.
この相互作用をわかりやすく説明すると
Nizatidine and Rilpivirine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nizatidine belongs to Gastrointestinal Tract; Rilpivirine belongs to Anti Virals.
なぜ起こるのか
Elevated gastric pH reduces the solubility and absorption of rilpivirine.
対処法
Take nizatidine at least 12 hours before or at least 4 hours after rilpivirine. Monitor HIV viral load.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、NizatidineとRilpivirineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Nizatidineのその他の相互作用
Rilpivirineのその他の相互作用
よくある質問
Can I take Nizatidine with Rilpivirine?
MediHelp rates the interaction as major. Nizatidine and Rilpivirine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rilpivirine needs an acidic stomach for adequate absorption, and nizatidine raises gastric pH. Lower rilpivirine levels may lead to virologic failure and development of resistance.
How serious is the interaction between Nizatidine and Rilpivirine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take nizatidine at least 12 hours before or at least 4 hours after rilpivirine. Monitor HIV viral load.
What other medicines interact with Nizatidine?
MediHelp also lists interactions of Nizatidine with, for example, Atazanavir, Dasatinib, Erlotinib. The full list is on the Nizatidine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
