相互作用
Defibrotide + Enoxaparin
重症度: 併用禁忌
Defibrotide and Enoxaparin: contraindicated interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Defibrotide has profibrinolytic and antithrombotic activity, so combining it with enoxaparin at treatment doses raises hemorrhage risk. Labeling contraindicates concurrent systemic anticoagulant therapy.
この相互作用をわかりやすく説明すると
Defibrotide and Enoxaparin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Defibrotide belongs to Cardiovascular; Enoxaparin belongs to Cardiovascular.
なぜ起こるのか
Additive pharmacodynamic effects on hemostasis.
対処法
Hold therapeutic enoxaparin during defibrotide treatment and reassess the need for anticoagulation.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DefibrotideとEnoxaparinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Enoxaparinのその他の相互作用
Defibrotideのその他の相互作用
よくある質問
Can I take Defibrotide with Enoxaparin?
MediHelp rates the interaction as contraindicated. Defibrotide and Enoxaparin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Defibrotide has profibrinolytic and antithrombotic activity, so combining it with enoxaparin at treatment doses raises hemorrhage risk. Labeling contraindicates concurrent systemic anticoagulant therapy.
How serious is the interaction between Defibrotide and Enoxaparin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold therapeutic enoxaparin during defibrotide treatment and reassess the need for anticoagulation.
What other medicines interact with Enoxaparin?
MediHelp also lists interactions of Enoxaparin with, for example, Ketorolac, Mifepristone, Abciximab. The full list is on the Enoxaparin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
