相互作用
Dalteparin + Defibrotide
重症度: 併用禁忌
Dalteparin and Defibrotide: contraindicated interaction.
最終更新日
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概要
Defibrotide has profibrinolytic and antithrombotic activity, and combining it with a low molecular weight heparin adds to the risk of bleeding. Labeling for defibrotide contraindicates concurrent systemic antithrombotic or fibrinolytic therapy.
この相互作用をわかりやすく説明すると
Dalteparin and Defibrotide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dalteparin belongs to Cardiovascular; Defibrotide belongs to Cardiovascular.
なぜ起こるのか
Additive pharmacodynamic effects on hemostasis from anticoagulation plus enhanced fibrinolysis.
対処法
Do not give together; hold dalteparin around defibrotide therapy and use an alternative plan. Routine maintenance or reopening of central venous lines is the usual exception.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DalteparinとDefibrotideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Dalteparinのその他の相互作用
Defibrotideのその他の相互作用
よくある質問
Can I take Dalteparin with Defibrotide?
MediHelp rates the interaction as contraindicated. Dalteparin and Defibrotide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Defibrotide has profibrinolytic and antithrombotic activity, and combining it with a low molecular weight heparin adds to the risk of bleeding. Labeling for defibrotide contraindicates concurrent systemic antithrombotic or fibrinolytic therapy.
How serious is the interaction between Dalteparin and Defibrotide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give together; hold dalteparin around defibrotide therapy and use an alternative plan. Routine maintenance or reopening of central venous lines is the usual exception.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Ketorolac, Mifepristone, Abciximab. The full list is on the Dalteparin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
