相互作用
Apixaban + Defibrotide
重症度: 併用禁忌
Apixaban and Defibrotide: contraindicated interaction.
最終更新日
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概要
Defibrotide has antithrombotic and profibrinolytic effects, so adding apixaban increases the risk of serious bleeding. Defibrotide labeling contraindicates concurrent systemic anticoagulants.
この相互作用をわかりやすく説明すると
Apixaban and Defibrotide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Apixaban belongs to Cardiovascular; Defibrotide belongs to Cardiovascular.
なぜ起こるのか
Additive pharmacodynamic effects on hemostasis from factor Xa inhibition plus enhanced fibrinolysis.
対処法
Do not co-administer; interrupt apixaban during defibrotide therapy under specialist guidance. Central line maintenance is the usual exception.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ApixabanとDefibrotideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Apixabanのその他の相互作用
Defibrotideのその他の相互作用
よくある質問
Can I take Apixaban with Defibrotide?
MediHelp rates the interaction as contraindicated. Apixaban and Defibrotide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Defibrotide has antithrombotic and profibrinolytic effects, so adding apixaban increases the risk of serious bleeding. Defibrotide labeling contraindicates concurrent systemic anticoagulants.
How serious is the interaction between Apixaban and Defibrotide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; interrupt apixaban during defibrotide therapy under specialist guidance. Central line maintenance is the usual exception.
What other medicines interact with Apixaban?
MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Edoxaban, Ketorolac. The full list is on the Apixaban page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
