相互作用
Defibrotide + Edoxaban
重症度: 併用禁忌
Defibrotide and Edoxaban: contraindicated interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Defibrotide has profibrinolytic and antithrombotic activity and may add to the bleeding risk of anticoagulants such as edoxaban. Defibrotide labeling contraindicates concomitant systemic anticoagulants or fibrinolytics. Serious hemorrhage is the concern.
この相互作用をわかりやすく説明すると
Defibrotide and Edoxaban are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Defibrotide belongs to Cardiovascular; Edoxaban belongs to Cardiovascular.
なぜ起こるのか
Additive pharmacodynamic effects on hemostasis from factor Xa inhibition and defibrotide's profibrinolytic activity.
対処法
Do not co-administer; hold edoxaban while defibrotide is being given. Resume anticoagulation only after defibrotide therapy is finished and bleeding risk has been reassessed.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DefibrotideとEdoxabanの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Edoxabanのその他の相互作用
Defibrotideのその他の相互作用
よくある質問
Can I take Defibrotide with Edoxaban?
MediHelp rates the interaction as contraindicated. Defibrotide and Edoxaban are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Defibrotide has profibrinolytic and antithrombotic activity and may add to the bleeding risk of anticoagulants such as edoxaban. Defibrotide labeling contraindicates concomitant systemic anticoagulants or fibrinolytics. Serious hemorrhage is the concern.
How serious is the interaction between Defibrotide and Edoxaban?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; hold edoxaban while defibrotide is being given. Resume anticoagulation only after defibrotide therapy is finished and bleeding risk has been reassessed.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Ketorolac, Abciximab. The full list is on the Edoxaban page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
