相互作用
Defibrotide + Fondaparinux
重症度: 併用禁忌
Defibrotide and Fondaparinux: contraindicated interaction.
最終更新日
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概要
Defibrotide enhances fibrinolysis and has antithrombotic effects, so with fondaparinux the risk of serious bleeding is increased. Defibrotide labeling contraindicates concurrent systemic anticoagulant or fibrinolytic therapy.
この相互作用をわかりやすく説明すると
Defibrotide and Fondaparinux are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Defibrotide belongs to Cardiovascular; Fondaparinux belongs to Cardiovascular.
なぜ起こるのか
Additive pharmacodynamic effects on hemostasis through factor Xa inhibition plus enhanced fibrinolysis.
対処法
Do not co-administer; hold fondaparinux during defibrotide treatment or use an alternative plan. Line maintenance or reopening of central lines is the usual exception.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DefibrotideとFondaparinuxの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Fondaparinuxのその他の相互作用
Defibrotideのその他の相互作用
よくある質問
Can I take Defibrotide with Fondaparinux?
MediHelp rates the interaction as contraindicated. Defibrotide and Fondaparinux are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Defibrotide enhances fibrinolysis and has antithrombotic effects, so with fondaparinux the risk of serious bleeding is increased. Defibrotide labeling contraindicates concurrent systemic anticoagulant or fibrinolytic therapy.
How serious is the interaction between Defibrotide and Fondaparinux?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; hold fondaparinux during defibrotide treatment or use an alternative plan. Line maintenance or reopening of central lines is the usual exception.
What other medicines interact with Fondaparinux?
MediHelp also lists interactions of Fondaparinux with, for example, Ketorolac, Abciximab, Aceclofenac. The full list is on the Fondaparinux page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
