相互作用
Desipramine + Isocarboxazid
重症度: 併用禁忌
Desipramine and Isocarboxazid: contraindicated interaction.
最終更新日
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概要
Isocarboxazid inhibits monoamine oxidase and so reduces serotonin breakdown, while desipramine is a tricyclic antidepressant that blocks norepinephrine reuptake and, to a lesser degree, serotonin reuptake. Together this can precipitate serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability that may be fatal. Hypertensive reactions are also possible with tricyclic agents.
この相互作用をわかりやすく説明すると
Desipramine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Desipramine belongs to Central Nervous System; Isocarboxazid belongs to Central Nervous System.
なぜ起こるのか
Additive serotonergic activity: irreversible non-selective MAO inhibition plus monoamine reuptake inhibition
対処法
Do not combine; allow at least 14 days after stopping the isocarboxazid before starting desipramine, and at least 14 days after stopping desipramine before starting the isocarboxazid.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DesipramineとIsocarboxazidの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Desipramineのその他の相互作用
Isocarboxazidのその他の相互作用
よくある質問
Can I take Desipramine with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Desipramine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Isocarboxazid inhibits monoamine oxidase and so reduces serotonin breakdown, while desipramine is a tricyclic antidepressant that blocks norepinephrine reuptake and, to a lesser degree, serotonin reuptake. Together this can precipitate serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability that may be fatal. Hypertensive reactions are also possible with tricyclic agents.
How serious is the interaction between Desipramine and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; allow at least 14 days after stopping the isocarboxazid before starting desipramine, and at least 14 days after stopping desipramine before starting the isocarboxazid.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
