相互作用
Desloratadine + Tranylcypromine
重症度: 中等度
Desloratadine and Tranylcypromine: moderate interaction.
最終更新日
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概要
MAO inhibitors may intensify and prolong the anticholinergic and sedative effects of antihistamines. Desloratadine is non-sedating at usual doses, so the effect is generally mild.
この相互作用をわかりやすく説明すると
Desloratadine and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desloratadine belongs to Respiratory; Tranylcypromine belongs to Central Nervous System.
なぜ起こるのか
Additive pharmacodynamic CNS depression, with MAO inhibition possibly potentiating antihistamine anticholinergic effects.
対処法
Monitor for drowsiness and anticholinergic symptoms such as dry mouth or urinary retention. Advise caution with driving until the response is known.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、DesloratadineとTranylcypromineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Desloratadineのその他の相互作用
Tranylcypromineのその他の相互作用
よくある質問
Can I take Desloratadine with Tranylcypromine?
MediHelp rates the interaction as moderate. Desloratadine and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors may intensify and prolong the anticholinergic and sedative effects of antihistamines. Desloratadine is non-sedating at usual doses, so the effect is generally mild.
How serious is the interaction between Desloratadine and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for drowsiness and anticholinergic symptoms such as dry mouth or urinary retention. Advise caution with driving until the response is known.
What other medicines interact with Desloratadine?
MediHelp also lists interactions of Desloratadine with, for example, Erdafitinib, Isocarboxazid, Zuranolone. The full list is on the Desloratadine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
