相互作用
Dexamethasone-neomycin-polymyxin + Lapatinib
重症度: 重大
Dexamethasone-neomycin-polymyxin and Lapatinib: major interaction.
最終更新日
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概要
Dexamethasone induces CYP3A4 and may substantially reduce lapatinib exposure, risking loss of efficacy. Lapatinib may modestly raise dexamethasone exposure through CYP3A4 and P-glycoprotein inhibition.
この相互作用をわかりやすく説明すると
Dexamethasone-neomycin-polymyxin and Lapatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Lapatinib belongs to Oncology.
なぜ起こるのか
Dexamethasone induces CYP3A4 and increases lapatinib clearance, while lapatinib weakly inhibits CYP3A4 and P-glycoprotein.
対処法
Avoid prolonged systemic dexamethasone with lapatinib where possible, or consider a lapatinib dose increase per labeling for strong inducers. Monitor tumor response and corticosteroid effects.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Dexamethasone-neomycin-polymyxinとLapatinibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Dexamethasone-neomycin-polymyxinのその他の相互作用
- Dexamethasone-neomycin-polymyxin + Ketorolac 重大
- Dexamethasone-neomycin-polymyxin + Levofloxacin 重大
- Dexamethasone-neomycin-polymyxin + Mifepristone 重大
- Dexamethasone-neomycin-polymyxin + Moxifloxacin 重大
- Aldesleukin + Dexamethasone-neomycin-polymyxin 中等度
- Allogeneic cultured keratinocytes / fibroblasts in bovine collagen + Dexamethasone-neomycin-polymyxin 中等度
Lapatinibのその他の相互作用
よくある質問
Can I take Dexamethasone-neomycin-polymyxin with Lapatinib?
MediHelp rates the interaction as major. Dexamethasone-neomycin-polymyxin and Lapatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dexamethasone induces CYP3A4 and may substantially reduce lapatinib exposure, risking loss of efficacy. Lapatinib may modestly raise dexamethasone exposure through CYP3A4 and P-glycoprotein inhibition.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Lapatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged systemic dexamethasone with lapatinib where possible, or consider a lapatinib dose increase per labeling for strong inducers. Monitor tumor response and corticosteroid effects.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Levofloxacin, Mifepristone. The full list is on the Dexamethasone-neomycin-polymyxin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
