相互作用
Dexamethasone-neomycin-polymyxin + Levofloxacin
重症度: 重大
Dexamethasone-neomycin-polymyxin and Levofloxacin: major interaction.
最終更新日
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概要
Fluoroquinolones and systemic corticosteroids together increase the risk of tendinitis and tendon rupture, particularly the Achilles tendon. Risk is higher in older patients and those on prolonged therapy.
この相互作用をわかりやすく説明すると
Dexamethasone-neomycin-polymyxin and Levofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Levofloxacin belongs to Anti Bacterial.
なぜ起こるのか
Additive tendon toxicity from fluoroquinolone effects on tenocytes and corticosteroid-impaired collagen turnover.
対処法
Avoid the combination in older patients where alternatives exist. Stop levofloxacin at the first sign of tendon pain or inflammation and rest the limb.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Dexamethasone-neomycin-polymyxinとLevofloxacinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Dexamethasone-neomycin-polymyxinのその他の相互作用
- Dexamethasone-neomycin-polymyxin + Ketorolac 重大
- Dexamethasone-neomycin-polymyxin + Lapatinib 重大
- Dexamethasone-neomycin-polymyxin + Mifepristone 重大
- Dexamethasone-neomycin-polymyxin + Moxifloxacin 重大
- Aldesleukin + Dexamethasone-neomycin-polymyxin 中等度
- Allogeneic cultured keratinocytes / fibroblasts in bovine collagen + Dexamethasone-neomycin-polymyxin 中等度
Levofloxacinのその他の相互作用
よくある質問
Can I take Dexamethasone-neomycin-polymyxin with Levofloxacin?
MediHelp rates the interaction as major. Dexamethasone-neomycin-polymyxin and Levofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluoroquinolones and systemic corticosteroids together increase the risk of tendinitis and tendon rupture, particularly the Achilles tendon. Risk is higher in older patients and those on prolonged therapy.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Levofloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in older patients where alternatives exist. Stop levofloxacin at the first sign of tendon pain or inflammation and rest the limb.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Mifepristone. The full list is on the Dexamethasone-neomycin-polymyxin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
