相互作用
Dexamethasone-neomycin-polymyxin + Ketorolac
重症度: 重大
Dexamethasone-neomycin-polymyxin and Ketorolac: major interaction.
最終更新日
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概要
Ketorolac carries a high intrinsic risk of GI ulceration and bleeding, and corticosteroids add to this risk. The combination is of concern with systemic exposure to dexamethasone.
この相互作用をわかりやすく説明すると
Dexamethasone-neomycin-polymyxin and Ketorolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Ketorolac belongs to Musculoskeletal.
なぜ起こるのか
Additive gastrointestinal mucosal injury from corticosteroids and potent NSAID prostaglandin inhibition.
対処法
Keep ketorolac to the shortest course allowed by labeling and consider gastroprotection with a proton pump inhibitor. Avoid in patients with prior ulcer or GI bleed.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Dexamethasone-neomycin-polymyxinとKetorolacの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Dexamethasone-neomycin-polymyxinのその他の相互作用
- Dexamethasone-neomycin-polymyxin + Lapatinib 重大
- Dexamethasone-neomycin-polymyxin + Levofloxacin 重大
- Dexamethasone-neomycin-polymyxin + Mifepristone 重大
- Dexamethasone-neomycin-polymyxin + Moxifloxacin 重大
- Aldesleukin + Dexamethasone-neomycin-polymyxin 中等度
- Allogeneic cultured keratinocytes / fibroblasts in bovine collagen + Dexamethasone-neomycin-polymyxin 中等度
Ketorolacのその他の相互作用
よくある質問
Can I take Dexamethasone-neomycin-polymyxin with Ketorolac?
MediHelp rates the interaction as major. Dexamethasone-neomycin-polymyxin and Ketorolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ketorolac carries a high intrinsic risk of GI ulceration and bleeding, and corticosteroids add to this risk. The combination is of concern with systemic exposure to dexamethasone.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Ketorolac?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep ketorolac to the shortest course allowed by labeling and consider gastroprotection with a proton pump inhibitor. Avoid in patients with prior ulcer or GI bleed.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Lapatinib, Levofloxacin, Mifepristone. The full list is on the Dexamethasone-neomycin-polymyxin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
