相互作用
Dexlansoprazole + Gefitinib
重症度: 重大
Dexlansoprazole and Gefitinib: major interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Gefitinib needs an acidic stomach for adequate absorption, and acid suppression with a PPI lowers its exposure markedly. This may reduce anticancer efficacy.
この相互作用をわかりやすく説明すると
Dexlansoprazole and Gefitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dexlansoprazole belongs to Gastrointestinal Tract; Gefitinib belongs to Oncology.
なぜ起こるのか
Increased gastric pH reduces gefitinib solubility and absorption.
対処法
Avoid PPIs if possible. If one is required, take gefitinib 12 hours after the PPI dose, though this may not fully prevent the effect.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DexlansoprazoleとGefitinibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Dexlansoprazoleのその他の相互作用
Gefitinibのその他の相互作用
よくある質問
Can I take Dexlansoprazole with Gefitinib?
MediHelp rates the interaction as major. Dexlansoprazole and Gefitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gefitinib needs an acidic stomach for adequate absorption, and acid suppression with a PPI lowers its exposure markedly. This may reduce anticancer efficacy.
How serious is the interaction between Dexlansoprazole and Gefitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs if possible. If one is required, take gefitinib 12 hours after the PPI dose, though this may not fully prevent the effect.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
