相互作用
Gefitinib + Omeprazole
重症度: 重大
Gefitinib and Omeprazole: major interaction.
最終更新日
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概要
Gefitinib absorption depends on gastric acidity, and raising gastric pH substantially lowers its exposure. This may reduce anti-tumour efficacy.
この相互作用をわかりやすく説明すると
Gefitinib and Omeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gefitinib belongs to Oncology; Omeprazole belongs to Gastrointestinal Tract.
なぜ起こるのか
Omeprazole raises gastric pH, decreasing gefitinib solubility and absorption.
対処法
Avoid PPIs if possible. If one is needed, take gefitinib 12 hours after the PPI dose, though H2 antagonists or antacids with timed separation are preferable.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、GefitinibとOmeprazoleの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Omeprazoleのその他の相互作用
Gefitinibのその他の相互作用
よくある質問
Can I take Gefitinib with Omeprazole?
MediHelp rates the interaction as major. Gefitinib and Omeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gefitinib absorption depends on gastric acidity, and raising gastric pH substantially lowers its exposure. This may reduce anti-tumour efficacy.
How serious is the interaction between Gefitinib and Omeprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs if possible. If one is needed, take gefitinib 12 hours after the PPI dose, though H2 antagonists or antacids with timed separation are preferable.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
