相互作用
Apalutamide + Gefitinib
重症度: 重大
Apalutamide and Gefitinib: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Apalutamide may substantially lower gefitinib plasma concentrations and thereby reduce antitumor efficacy in EGFR-mutated lung cancer.
この相互作用をわかりやすく説明すると
Apalutamide and Gefitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apalutamide belongs to Endocrine; Gefitinib belongs to Oncology.
なぜ起こるのか
Apalutamide induces CYP3A4, the main enzyme metabolizing gefitinib.
対処法
Avoid the combination if possible; if required, gefitinib labeling suggests increasing to 500 mg daily with strong inducers and monitoring tolerance.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ApalutamideとGefitinibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Apalutamideのその他の相互作用
Gefitinibのその他の相互作用
よくある質問
Can I take Apalutamide with Gefitinib?
MediHelp rates the interaction as major. Apalutamide and Gefitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide may substantially lower gefitinib plasma concentrations and thereby reduce antitumor efficacy in EGFR-mutated lung cancer.
How serious is the interaction between Apalutamide and Gefitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; if required, gefitinib labeling suggests increasing to 500 mg daily with strong inducers and monitoring tolerance.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
