相互作用
Dichlorphenamide + Glipizide-metformin
重症度: 重大
Dichlorphenamide and Glipizide-metformin: major interaction.
最終更新日
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概要
Dichlorphenamide is a carbonic anhydrase inhibitor that causes hyperchloremic metabolic acidosis. Combined with metformin, which carries a risk of lactic acidosis, acid-base disturbance may be worsened.
この相互作用をわかりやすく説明すると
Dichlorphenamide and Glipizide-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dichlorphenamide belongs to Miscellaneous; Glipizide-metformin belongs to Endocrine.
なぜ起こるのか
Additive pharmacodynamic risk of acidosis through carbonic anhydrase inhibition and metformin-related lactate accumulation.
対処法
Monitor serum bicarbonate and electrolytes at baseline and periodically, and reassess the need for metformin if acidosis develops. Avoid the combination in patients with renal impairment.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DichlorphenamideとGlipizide-metforminの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Glipizide-metforminのその他の相互作用
Dichlorphenamideのその他の相互作用
よくある質問
Can I take Dichlorphenamide with Glipizide-metformin?
MediHelp rates the interaction as major. Dichlorphenamide and Glipizide-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dichlorphenamide is a carbonic anhydrase inhibitor that causes hyperchloremic metabolic acidosis. Combined with metformin, which carries a risk of lactic acidosis, acid-base disturbance may be worsened.
How serious is the interaction between Dichlorphenamide and Glipizide-metformin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum bicarbonate and electrolytes at baseline and periodically, and reassess the need for metformin if acidosis develops. Avoid the combination in patients with renal impairment.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
