相互作用
Dichlorphenamide + Vitamin B12
重症度: 中等度
Dichlorphenamide and Vitamin B12: moderate interaction.
最終更新日
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概要
Dichlorphenamide commonly causes potassium loss through its carbonic anhydrase inhibition. Cyanocobalamin can lower potassium when treating severe megaloblastic anemia because of rapid cell production, so low potassium is possible when both are used. This is mainly relevant at initiation of B12 therapy in severely deficient patients.
この相互作用をわかりやすく説明すると
Dichlorphenamide and Vitamin B12 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Vitamin B12 belongs to Gastrointestinal Tract.
なぜ起こるのか
Additive hypokalemia: renal potassium wasting from carbonic anhydrase inhibition plus increased cellular potassium uptake during hematopoietic recovery after B12 replacement.
対処法
Check serum potassium before and during early B12 repletion in patients on dichlorphenamide. Replace potassium as needed.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DichlorphenamideとVitamin B12の臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Vitamin B12のその他の相互作用
Dichlorphenamideのその他の相互作用
よくある質問
Can I take Dichlorphenamide with Vitamin B12?
MediHelp rates the interaction as moderate. Dichlorphenamide and Vitamin B12 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide commonly causes potassium loss through its carbonic anhydrase inhibition. Cyanocobalamin can lower potassium when treating severe megaloblastic anemia because of rapid cell production, so low potassium is possible when both are used. This is mainly relevant at initiation of B12 therapy in severely deficient patients.
How serious is the interaction between Dichlorphenamide and Vitamin B12?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium before and during early B12 repletion in patients on dichlorphenamide. Replace potassium as needed.
What other medicines interact with Vitamin B12?
MediHelp also lists interactions of Vitamin B12 with, for example, Chloramphenicol, Metformin, Neomycin po. The full list is on the Vitamin B12 page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
