相互作用
Dienogest / estradiol valerate + Efavirenz
重症度: 併用禁忌
Dienogest / estradiol valerate and Efavirenz: contraindicated interaction.
最終更新日
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概要
Efavirenz induces CYP3A4 and may lower dienogest and estradiol concentrations. This can reduce contraceptive efficacy and risk unintended pregnancy, and the inducing effect persists after efavirenz is stopped.
この相互作用をわかりやすく説明すると
Dienogest / estradiol valerate and Efavirenz are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Induction of CYP3A4 metabolism of dienogest and estradiol by efavirenz.
対処法
Do not rely on this product for contraception during efavirenz therapy; use an alternative method such as an intrauterine device. Continue the alternative method for several weeks after stopping efavirenz.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Dienogest / estradiol valerateとEfavirenzの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Efavirenzのその他の相互作用
よくある質問
Can I take Dienogest / estradiol valerate with Efavirenz?
MediHelp rates the interaction as contraindicated. Dienogest / estradiol valerate and Efavirenz are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Efavirenz induces CYP3A4 and may lower dienogest and estradiol concentrations. This can reduce contraceptive efficacy and risk unintended pregnancy, and the inducing effect persists after efavirenz is stopped.
How serious is the interaction between Dienogest / estradiol valerate and Efavirenz?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not rely on this product for contraception during efavirenz therapy; use an alternative method such as an intrauterine device. Continue the alternative method for several weeks after stopping efavirenz.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Efavirenz page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
