相互作用
Dihydroergotamine intranasal + Efavirenz
重症度: 併用禁忌
Dihydroergotamine intranasal and Efavirenz: contraindicated interaction.
最終更新日
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概要
Efavirenz alters CYP3A4 activity and may change systemic dihydroergotamine exposure unpredictably. Elevated ergot levels risk serious vasospastic ischemia.
この相互作用をわかりやすく説明すると
Dihydroergotamine intranasal and Efavirenz are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Efavirenz modulation of CYP3A4 metabolism of dihydroergotamine.
対処法
Avoid and choose a non-ergot migraine therapy.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Dihydroergotamine intranasalとEfavirenzの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Efavirenzのその他の相互作用
よくある質問
Can I take Dihydroergotamine intranasal with Efavirenz?
MediHelp rates the interaction as contraindicated. Dihydroergotamine intranasal and Efavirenz are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Efavirenz alters CYP3A4 activity and may change systemic dihydroergotamine exposure unpredictably. Elevated ergot levels risk serious vasospastic ischemia.
How serious is the interaction between Dihydroergotamine intranasal and Efavirenz?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid and choose a non-ergot migraine therapy.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine. The full list is on the Efavirenz page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
