相互作用
Dihydroergotamine + Efavirenz
重症度: 併用禁忌
Dihydroergotamine and Efavirenz: contraindicated interaction.
最終更新日
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概要
Efavirenz alters CYP3A4 activity and may change dihydroergotamine exposure unpredictably. Elevated ergot levels risk severe peripheral and cerebral ischemia, so the combination is avoided.
この相互作用をわかりやすく説明すると
Dihydroergotamine and Efavirenz are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dihydroergotamine belongs to Central Nervous System; Efavirenz belongs to Anti Virals.
なぜ起こるのか
Efavirenz modulation of CYP3A4 metabolism of dihydroergotamine.
対処法
Avoid and treat migraine with a non-ergot alternative such as a triptan, taking its interactions into account.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、DihydroergotamineとEfavirenzの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Efavirenzのその他の相互作用
Dihydroergotamineのその他の相互作用
よくある質問
Can I take Dihydroergotamine with Efavirenz?
MediHelp rates the interaction as contraindicated. Dihydroergotamine and Efavirenz are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Efavirenz alters CYP3A4 activity and may change dihydroergotamine exposure unpredictably. Elevated ergot levels risk severe peripheral and cerebral ischemia, so the combination is avoided.
How serious is the interaction between Dihydroergotamine and Efavirenz?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid and treat migraine with a non-ergot alternative such as a triptan, taking its interactions into account.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
