相互作用
Diflunisal + Pralatrexate
重症度: 重大
Diflunisal and Pralatrexate: major interaction.
最終更新日
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概要
NSAIDs can delay renal elimination of pralatrexate, raising its exposure and the risk of toxicities such as mucositis and myelosuppression.
この相互作用をわかりやすく説明すると
Diflunisal and Pralatrexate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Diflunisal belongs to Musculoskeletal; Pralatrexate belongs to Oncology.
なぜ起こるのか
Competition for renal tubular secretion and NSAID-related reduction in renal blood flow decrease pralatrexate clearance.
対処法
Avoid the combination if possible; otherwise monitor for pralatrexate toxicity and renal function and adjust the pralatrexate dose as needed.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DiflunisalとPralatrexateの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Diflunisalのその他の相互作用
Pralatrexateのその他の相互作用
よくある質問
Can I take Diflunisal with Pralatrexate?
MediHelp rates the interaction as major. Diflunisal and Pralatrexate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs can delay renal elimination of pralatrexate, raising its exposure and the risk of toxicities such as mucositis and myelosuppression.
How serious is the interaction between Diflunisal and Pralatrexate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; otherwise monitor for pralatrexate toxicity and renal function and adjust the pralatrexate dose as needed.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
