相互作用
Disopyramide + Octreotide
重症度: 重大
Disopyramide and Octreotide: major interaction.
最終更新日
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概要
Octreotide can cause bradycardia and conduction abnormalities and has been associated with QT prolongation, while disopyramide prolongs QT and can cause torsades de pointes. Combined use may raise arrhythmia risk, especially with electrolyte disturbances.
この相互作用をわかりやすく説明すると
Disopyramide and Octreotide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Disopyramide belongs to Cardiovascular; Octreotide belongs to Endocrine.
なぜ起こるのか
Additive effects on cardiac repolarization and conduction, plus octreotide-related bradycardia.
対処法
Avoid if possible; otherwise obtain baseline and follow-up ECGs and correct potassium and magnesium.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DisopyramideとOctreotideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を7日間無料でお試し。カード登録不要。
Octreotideのその他の相互作用
Disopyramideのその他の相互作用
よくある質問
Can I take Disopyramide with Octreotide?
MediHelp rates the interaction as major. Disopyramide and Octreotide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Octreotide can cause bradycardia and conduction abnormalities and has been associated with QT prolongation, while disopyramide prolongs QT and can cause torsades de pointes. Combined use may raise arrhythmia risk, especially with electrolyte disturbances.
How serious is the interaction between Disopyramide and Octreotide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise obtain baseline and follow-up ECGs and correct potassium and magnesium.
What other medicines interact with Octreotide?
MediHelp also lists interactions of Octreotide with, for example, Adagrasib, Amisulpride, Arsenic trioxide. The full list is on the Octreotide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
