相互作用
Arsenic trioxide + Octreotide
重症度: 重大
Arsenic trioxide and Octreotide: major interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Arsenic trioxide carries a boxed warning for QT prolongation and torsades de pointes, and octreotide can add to this through bradycardia and QT effects. The combination raises the risk of serious ventricular arrhythmia.
この相互作用をわかりやすく説明すると
Arsenic trioxide and Octreotide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Arsenic trioxide belongs to Oncology; Octreotide belongs to Endocrine.
なぜ起こるのか
Additive QT prolongation, with octreotide-related bradycardia increasing torsades risk.
対処法
Avoid the combination where possible. If it is necessary, obtain a baseline ECG, keep potassium and magnesium within normal range, and monitor ECG throughout therapy.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Arsenic trioxideとOctreotideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Octreotideのその他の相互作用
Arsenic trioxideのその他の相互作用
よくある質問
Can I take Arsenic trioxide with Octreotide?
MediHelp rates the interaction as major. Arsenic trioxide and Octreotide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Arsenic trioxide carries a boxed warning for QT prolongation and torsades de pointes, and octreotide can add to this through bradycardia and QT effects. The combination raises the risk of serious ventricular arrhythmia.
How serious is the interaction between Arsenic trioxide and Octreotide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If it is necessary, obtain a baseline ECG, keep potassium and magnesium within normal range, and monitor ECG throughout therapy.
What other medicines interact with Octreotide?
MediHelp also lists interactions of Octreotide with, for example, Adagrasib, Amisulpride, Artemether / lumefantrine. The full list is on the Octreotide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
