相互作用
Disopyramide + Trimipramine
重症度: 併用禁忌
Disopyramide and Trimipramine: contraindicated interaction.
最終更新日
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概要
Disopyramide prolongs the QT interval and has negative inotropic and anticholinergic effects that overlap with trimipramine. Combined use raises the risk of torsades de pointes and conduction disturbance.
この相互作用をわかりやすく説明すると
Disopyramide and Trimipramine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Disopyramide belongs to Cardiovascular; Trimipramine belongs to Central Nervous System.
なぜ起こるのか
Additive QT prolongation and sodium channel blockade, plus additive anticholinergic effects.
対処法
Avoid the combination and use alternatives. If unavoidable, monitor ECG and electrolytes closely.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DisopyramideとTrimipramineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Trimipramineのその他の相互作用
Disopyramideのその他の相互作用
よくある質問
Can I take Disopyramide with Trimipramine?
MediHelp rates the interaction as contraindicated. Disopyramide and Trimipramine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Disopyramide prolongs the QT interval and has negative inotropic and anticholinergic effects that overlap with trimipramine. Combined use raises the risk of torsades de pointes and conduction disturbance.
How serious is the interaction between Disopyramide and Trimipramine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use alternatives. If unavoidable, monitor ECG and electrolytes closely.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Dofetilide, Ibutilide, Isocarboxazid. The full list is on the Trimipramine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
